منابع مشابه
Cutaneous melanomas associated with nevi.
OBJECTIVE To determine the frequency of and the histologic and clinical factors associated with melanoma existing in histologic contiguity with a nevus. DESIGN Pathology reports from melanomas collected from January 1, 1993, to December 31, 1997, were retrospectively reviewed. SETTING Independent, community-based dermatopathology laboratory. PATIENTS A total of 1606 patients with a histol...
متن کاملEstrogen Receptor Beta Expression in Melanomas Versus Dysplastic Nevi
Dear Editor-in-ChiefMalignant melanoma is a tumor arising from melanocyte; this tumor rarely occurs before puberty, with higher mortality rate in males and better survival rate in female patients affected by metastatic melanoma (1, 2). These facts propose that a relationship and association may exist between estrogens and melanoma. The effects of estrogens are mediated by...
متن کاملDNA-methylation profiling distinguishes malignant melanomas from benign nevi
DNA methylation, an epigenetic alteration typically occurring early in cancer development, could aid in the molecular diagnosis of melanoma. We determined technical feasibility for high-throughput DNA-methylation array-based profiling using formalin-fixed paraffin-embedded tissues for selection of candidate DNA-methylation differences between melanomas and nevi. Promoter methylation was evaluat...
متن کاملImmunohistochemical studies of conjunctival nevi and melanomas.
OBJECTIVE To evaluate the role of immunohistochemical methods in the diagnosis of benign and malignant conjunctival melanocytic proliferations. DESIGN Retrospective immunohistopathologic study. METHODS Paraffin-embedded tissue sections from 20 conjunctival nevi and 15 invasive melanomas were immunoreacted with antibodies against cellular antigens S-100 protein, MART-1, HMB-45, CD-45, and Ki...
متن کاملHuman nevi: no longer precursors of melanomas?
Considerable data support the idea that oncogene-induced senescence remains a barrier that needs to be overcome for malignant transformation of melanocytes. Human nevi stain positive for the senescence-associated β-galactosidase marker, suggesting that cells have lost their proliferative capacity. Most nevi harbor B-RAF or N-RAS mutations, implying that they are growth arrested via oncogene-ind...
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ژورنال
عنوان ژورنال: Dermatologic Clinics
سال: 2016
ISSN: 0733-8635
DOI: 10.1016/j.det.2016.05.003